| 第 35 卷第 3 期 |  | Vol. 35 No. 3 | | 2005 年 6 月 | Jun 2005 |
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所屬欄目：其它
2-氯-3-氰基吡啶的合成 |
| 劉振香; 蔡春(南京理工大學(xué)化工學(xué)院; 江蘇南京) |
| 摘 要：煙酰胺與雙氧水在冰醋酸中反應生成N-氧化煙酰胺(1),適宜的反應條件是煙酰胺∶雙氧水=1∶1.5(mol/mol),冰醋酸的用量為50 ml(煙酰胺用量5.0 g),反應時(shí)間為4h,收率80.6%;化合物1再與五氯化磷和三氯氧磷反應合成了2-氯-3-氰基吡啶(2),適宜的反應條件為N-氧化煙酰胺∶五氯化磷∶三氯氧磷=1∶1.7∶5.0(mol/mol),反應時(shí)間為2.0h,收率48.9%。 |
| 關(guān)鍵詞：煙酰胺; 氧化; N-氧化煙酰胺; 2-氯-3-氰基吡啶 |
| 中圖分類(lèi)號：O626.321 文獻標識碼：A 文章編號：1009-9212(2005)03-0028-03 |
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| Synthesis of 2-chloronicotinonitrile |
| LIU Zhen-xiang; CAI Chun（School of Chemical Engineering; Nanjing University of Science&Technology; Nanjing 210094; China） |
| Abstract：Nicotinamide-N-oxide (1) was prepared by oxidizing nicotinamide in the glacial acetic acid (AcOH) by 30% H_(2)O_(2).The reaction conditions recommended were as follow: the molar ratio of nicotinamide to H_(2)O_(2)was 1:1.5, amount of AcOH 50 ml (nicotinamide 5.0 g), reaction time 4 h, and the yield 80.6%. Treatment of the compound 1 with a mixture of phosphorus pentachloride and phosphorus oxychloride gave 2-chloronicotinonitrile (2), and the reaction conditions recommended were as follow: the molar ratio o... |
| Key words：Nicotinamide; oxidation; Nicotinamide-N-oxide; synthetize; 2-chloronicotinonitrile |
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收稿日期：2004-12-04
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