| 第 35 卷第 3 期 |  | Vol. 35 No. 3 | | 2005 年 6 月 | Jun 2005 |
|
所屬欄目：其它
1-溴-5-苯基-四氮唑的合成 |
| 魏先紅; 何寶娟; 陳泳洲(湖北師范學(xué)院化學(xué)與環(huán)境工程系; 湖北黃石) |
| 摘 要：以苯甲腈、疊氮鈉、溴等為原料,經(jīng)偶合,溴化合成了1-溴-5-苯基四氮唑。研究了反應時(shí)間、反應溫度、溶劑與反應物配比對產(chǎn)品收率的影響。實(shí)驗表明:在n(苯甲腈)∶n(疊氮鈉)=1∶1.1,1 mol NH4Cl催化,120℃下反應20 h可得到收率90%的5-苯基四氮唑。在n(5-苯基四氮唑)∶n(溴)∶n(氫氧化鈉)=1∶0.97∶0.96,反應4 h,水作溶劑的條件下,可得到56.4%的1-溴-5-苯基四氮唑,兩步反應后的總收率為49.1%。 |
| 關(guān)鍵詞：1-溴-5-苯基-四氮唑; 5-苯基-四氮唑; 合成 |
| 中圖分類(lèi)號：O626.28 文獻標識碼：A 文章編號：1009-9212(2005)03-0011-02 |
|
| Synthesis 1-Bromine -5-Phenyl-Tetrazole |
| WEI Xian-hong; HE Bao-juan; CHEN Yong-zhou（Hubei Normal University; Huangshi 435002; China） |
| Abstract：The product 1-Bromine -5-phenyl-tetrazole was synthesized from benzonitrile,Br_(2) and sodium azide by cyclization and bromization. The factors influencing the synthesis were discussed and the best reaction conditions were found out. The optimum conditions were as follow: molar ratio of benzonitrile to sodium azide was 1∶1.1, the catalyst adding was 1.0 mol NH_(4)Cl, the reaction temperature was 120 ℃, and reaction time was 20h, the yield of 5Phenyl-Tetrazole reached 90%; Molar ratio of 5-Phenyl-Tetrazole t... |
| Key words：1-bromine- 5-phenyl-tetrazole; 5-phenyl-tetrazole; Synthesis |
|
收稿日期：2004-12-03
|
| 閱讀全文 |
|