| 第 35 卷第 3 期 |  | Vol. 35 No. 3 | | 2005 年 6 月 | Jun 2005 |
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所屬欄目：專(zhuān)論與綜述
5-氨基水楊酸的合成方法 |
| 徐勇智; 史鐵鈞(合肥工業(yè)大學(xué)化工學(xué)院; 安徽合肥) |
| 摘 要：5-氨基水楊酸(5-ASA)是治療炎癥性腸病(IBD)的臨床首選藥物之一,對其制備工藝的研究具有重要的現實(shí)意義。筆者對合成5-ASA的主要方法:硝基還原法、Kolbe合成法、水楊酸偶氮物中間體還原法進(jìn)行了綜述,比較了3種方法在反應條件、收率、環(huán)保等方面的優(yōu)缺點(diǎn),并對今后的研究方向進(jìn)行了展望。 |
| 關(guān)鍵詞：硝化; 還原; 重氮化; 偶合; 環(huán)境保護 |
| 中圖分類(lèi)號：TQ245.6 文獻標識碼：A 文章編號：1009-9212(2005)03-0005-02 |
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| The synthesis Methods of 5-Amino Salicylic Acid |
| XU Yong-zhi; SHI Tie-jun（School of Chemical Engineering; Hefei University of Technology; Hefei 230009; China） |
| Abstract：5-Aminosalicylic acids was one of the preferred drugs in clinical, so it had important significance to investigate the process of its preparation. Firstly three main methods of synthesizing 5-Aminosalicylic acids such as nitro reduction, Kolbe, azobenzolsalicylic acid intermediate reduction methods were reviewed in this paper. Next their relative merits were compared in point of reaction conditions, yield and environmental protection. Finally the development and prospect of 5-Aminosalicylic acids were put f... |
| Key words：nitration; reduction; diazotization; coincidence; environmental protection |
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收稿日期：2005-01-05
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