| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
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所屬欄目：有機合成原料
1,7-庚二酸的合成研究 |
| 朱平華(淮海工學(xué)院化工系; 江蘇連云港) |
| 摘 要：以1,5-戊二醇,三溴化磷,氰化鉀為原料,18-冠-6為催化劑合成1,7-庚二酸。通過(guò)正交實(shí)驗給出優(yōu)惠合成條件:反應時(shí)間4h,反應溫度85℃,w(催化劑)=6%(相對于1,5-戊二醇),1,7-庚二酸的收率90%。 |
| 關(guān)鍵詞：1; 7-庚二酸; 合成; 相轉移催化劑 |
| 中圖分類(lèi)號：TQ225.147 文獻標識碼：A 文章編號：1009-9212(2005)04-0058-02 |
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| Synthesis of 1,7- Pimelic Acid |
| ZHU Ping-hua （Department of Chemical Engineering; Huaihai Insititute of Technology; Lianyungang 222005; China） |
| Abstract：1,7-pimelic acid was synthesized from 1,5-dihydorxypentane and phosphorus (III) bromide and potassium cyanide with 1,4,7,10,13,16-hexaoxacyclooctadecane as catalyst. Optimal synthesis conditions were investigated by experiments using an orthogonal design. Yield of 1,7- pimelic acid were 90% under the optimal conditions such as reaction time 4h,temperature 85℃ and amount of catalyst 6% (based on1,5-dihydorxyppentane). |
| Key words：1; 7-pimelic acid; synthesis; the phase transfer catalyst |
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收稿日期：2005-03-24
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