| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
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所屬欄目：醫藥及中間體
新法合成4-羥基苯甘氨酸 |
| 伊汀; 朱春燕; 陳曉峰(上海寶鋼化工有限公司) |
| 摘 要：對以焦化苯酚為原料,氨基甲酸銨為氨化劑合成4-羥基苯甘氨酸的體系進(jìn)行了研究�？疾炝宋锪吓浔�、反應溫度、反應時(shí)間等主要因素對反應的影響,在原料配比為:1.4∶1,反應溫度為50￣70℃,反應時(shí)間為8h,返入N2保護,得到的產(chǎn)品純度>99%,反應易于控制,具有較高的應用價(jià)值。 |
| 關(guān)鍵詞：4-羥基苯甘氨酸; 氨基甲酸銨; 合成 |
| 中圖分類(lèi)號：TQ246.3+7 文獻標識碼：A 文章編號：1009-9212(2005)04-0020-02 |
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| A New Synthetic Process of 4- hydroxyphenylglycine |
| YI Ting; ZHU Chun-yan; CHEN Xiao-feng （Shanghai BaoChem Co; Ltd. Shanghai; Shanghai 200942; China） |
| Abstract：A new method for synthesis of 4-hydroxyphenylglycine was developed by amination in the presence of carbamic ammonium. Main factors influencing reaction were experimented.The optimum reactic condition was as follows:the ratio of phenol and is 1.4∶1(mol) temperature 50~70℃ reaction time 8 h.The purity of 4-hydroxyphenylglycine reached 99%,and the reaction conditions were easily controlled, which made it more suitable for industrial process. |
| Key words：4-hydroxyphenylglycine; carbamic ammonium; synthesis |
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收稿日期：2005-03-06
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