| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
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所屬欄目：醫藥及中間體
N-乙基-2,3-二氧代哌嗪的合成 |
| 許建幗; 謝建偉; 吳敏; 邵麗莉(浙江工業(yè)大學(xué)浙西分�；は�; 浙江巨化技術(shù)中心; 浙江衢州) |
| 摘 要：以N-乙基乙二胺和草酸二乙酯為原料,在氯化胺催化作用下脫醇縮合得N-乙基-2,3-二氧代哌嗪。實(shí)驗研究了反應物摩爾配比、反應時(shí)間、反應溫度、催化劑用量等對N-乙基-2,3-二氧代哌嗪收率影響,得出了優(yōu)惠工藝條件:催化劑用量為N-乙基乙二胺質(zhì)量的1.5%,原料草酸二乙醇與N-乙基乙二胺摩爾比為1.02∶1,反應溫度為20℃,乙酸用量200mL�？偸章蔬_到85%。 |
| 關(guān)鍵詞：N-乙基乙二胺; N-乙基-2; 3-二氧代哌嗪; 哌拉西林 |
| 中圖分類(lèi)號：TQ252 文獻標識碼：A 文章編號：1009-9212(2005)04-0018-02 |
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| Synthesis of N-ethyl-2,3-dioxopiperazine |
| XU Jian-guo1; XIE Jian-wei 1; WU Ming2; SHAO Li-li2 （1.Department of Chemical Enginering; West Branch of Zhejiang Industry University; Quzhou 324006; China; 2.Juhua Group Technology Center; Quzhou 324004; China） |
| Abstract：N-ethyl-2,3-dioxopiperazine was synthesized from N-ethylethylenediamine and diethyl ethanedioate by condensation reaction with catalyst ammonia chloride .The effects of mole ratios , reaction time, temperature and the amount of catalyst on the yields of N-ethyl-2,3-dioxopiperazine were investigated .The optimal condition was as follows:w(cat)=1.5%(N-alkylethylenediamin),n(diethylethanedioate):n(N-alkylethylenediamine)=1.02∶1,reaction temperature 20℃,ethanol zooml,The yield of N-ethy1-2,3-dioxopipevazine was... |
| Key words：N-ethyl-2; 3- dioxopiperazine; N-alkylethylenediamine; Piperacillin |
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收稿日期：2005-03-02
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