| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
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所屬欄目：醫藥及中間體
手性拆分劑L-二苯甲酰酒石酸和L-二乙酰酒石酸的合成工藝研究 |
| 呂秀娟; 梅璐璐; 施小新(華東理工大學(xué)化學(xué)與制藥學(xué)院) |
| 摘 要：研究了手性拆分劑L-二苯甲酰酒石酸和L-二乙酰酒石酸的合成工藝及各種反應條件對收率和產(chǎn)物旋光純度的影響。在路易斯酸催化下,L-酒石酸與苯甲酰氯及二氯亞砜作用生成L-二苯甲酰酒石酸酐,然后L-二苯甲酰酒石酸酐再水解成L-二苯甲酰酒石酸,二步總收率86%,旋光純度大于99%;在硫酸催化下,L-酒石酸與乙酐作用生成L-二乙酰酒石酸酐,再水解成L-二乙酰酒石酸,二步總收率為75%,旋光純度大于99%。 |
| 關(guān)鍵詞：L-二苯甲酰酒石酸; L-二乙酰酒石酸; 手性拆分劑; 合成 |
| 中圖分類(lèi)號：TQ225.4 文獻標識碼：A 文章編號：1009-9212(2005)04-0012-03 |
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| Practical Syntheses of L-Dibenzoyltartaric Acid and L-Diacetyltartaric Acid |
| LU Xiu-juan; MEI Lu-lu; SHI Xiao-xin （College of Chemistry and Pharmaceutical Engineering; East China University of Science and Technology; Shanghai 200237; China） |
| Abstract：The processes for syntheses of L-dibenzoyltartaric acid and L-diacetyltartaric acid were studied. The Lewis acid catalyzed reaction of L-tartaric acid with benzoyl chloride in the presence of thionyl dichloride in toluene gave smoothly L-dibenzoyltartaric anhydride that was then treated with water to afford L-dibenzoyltartaric acid. Its total yield and optical rotation was 86% and 99%, respectively. The reaction of L-tartaric acid with acetic anhydride in the presence of catalytic amount of sulfuric acid ga... |
| Key words：L-dibenzoyltartaric acid; L-diacetyltartaric acid; chiral resolving agent; syntheses |
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基金項目：上海市教育發(fā)展基金(No03SG27)
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收稿日期：2005-05-02
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