| 第 35 卷第 5 期 |  | Vol. 35 No. 5 | | 2005 年 10 月 | Oct 2005 |
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所屬欄目：有機合成原料
原位氧化氯化合成3-氯丁酮 |
| 鐘文周; 尹篤林; 徐瓊; 王季惠; 唐迪(湖南師范大學(xué)精細催化合成研究所教育部化學(xué)生物學(xué)及中藥分析重點(diǎn)實(shí)驗室; 湖南長(cháng)沙) |
| 摘 要：利用鹽酸-過(guò)氧化氫作反應物,通過(guò)原位氯化反應合成3-氯丁酮�？疾炝嗽吓� 比、反應時(shí)間、反應溫度、及金屬鹽的加入對反應結果的影響。以CuCl2作催化劑,丁酮、鹽酸、過(guò)氧 化氫的摩爾配比為2∶1∶1．3時(shí),回流溫度下反應5h,丁酮轉化率為52．43％,3-氯丁酮選擇性 達76％,分餾得到的產(chǎn)品的純度98％以上。 |
| 關(guān)鍵詞：氧化氯化; 鹽酸-過(guò)氧化氫; 3-氯丁酮 |
| 中圖分類(lèi)號：TQ224.5 文獻標識碼：A 文章編號：1009-9212(2005)05-0032-03 |
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| Synthesis of 3-chloro-2-butanone by oxidation-chlorination in situ |
| ZHONG Wen-zhou; YIN Du-lin; XU Qiong; WANG Ji-hui; TANG Di Institute of Fine Catalysis and Synthesis; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research; Hunan Normal University; Changsha 410081; China |
| Abstract：3-chloro-2-butanone was synthesized by chlorination in situ with HC1-H2O2. The influences of reaction conditions such as mole ratio, reaction time, reaction temperature and some metal salts were examined in detail. The optimum preparation conditions were CuCl2 as catalyst, n(butanone):n(HCl):n(H2O2)=2:l:1.3, reaction temperature 78℃ and reaction time is 5h. the conversion of butanone amount to 52.43%, the selectivity of 3-chloro-2-butanone is over 76% and its purity is over 98%. |
| Key words：oxidation-chlorination; HCl-H2O2; 3-chloro-2-butanone |
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收稿日期：2005-06-30
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