| 第 35 卷第 5 期 |  | Vol. 35 No. 5 | | 2005 年 10 月 | Oct 2005 |
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所屬欄目：醫藥及中間體
3,4-二甲氧基苯胺的合成 |
| 裘煒杰; 林軍(杭州電化集團股份有限公司; 浙江杭州) |
| 摘 要：以3,4-二甲氧基苯為原料。在0-5℃低溫條件下,以硝酸和硫酸按比例配成的混酸進(jìn) 行硝化,反應結束后過(guò)濾得到3,4-二甲氧基硝基苯,該步反應的收率有97％。然后以乙醇為溶劑, 雷尼鎳為催化劑,在1．6 MPa的氫氣壓力下,于高壓釜中100℃條件下通過(guò)催化加氫將3,4-二甲氧 基硝基苯還原為3,4-二甲氧基苯胺。該反應的收率達到90％以上,純度達到98％以上。 |
| 關(guān)鍵詞：3; 4-二甲氧基苯胺; 2-氯-4-氨基-6; 7-二甲氧基喹唑啉; 催化加氫; 鄰二甲氧基苯 |
| 中圖分類(lèi)號：TQ246.3 文獻標識碼：A 文章編號：1009-9212(2005)05-0028-02 |
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| Synthesis of 3,4-Dimethoxyaniline |
| QW Wei-jie; LIN Jun Hangzhou Electrochemical Group Ltd. Co.; Hangzhou 310053; China |
| Abstract：3,4-Dimethoxyaniline was prepared with 3, 4-dimethoxybenzene. The 3, 4-dimethoxybenzene was nitrated by mixed acid of HNO3-H2SO4 under the reaction temperature of 0-5℃. 3,4-dimethoxynitroben-zene was obtained by filtration, and its yield reached over 97%. 3, 4-Dimethoxynitrobenzene was dissolved in ethanol and reduced to the product 3,4-dimethoxyaniline using Raney-Ni as catalyst under the hydrogen pressure of 1.6 MPa in an autoclave (100℃). The yield and purity of 3, 4-dimethoxyanline was up to 90% and 98%... |
| Key words：3; 4-Dimethoxyaniline; 4-amino-2-chloro-6; 7-dimethoxy quinazoline; Catalytic hydrogen-ation; 4-dimethoxynitrobenzene; Synthesis |
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收稿日期：2005-05-28
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