| 第 35 卷第 5 期 |  | Vol. 35 No. 5 | | 2005 年 10 月 | Oct 2005 |
|
所屬欄目：專(zhuān)論與綜述
位阻型硅烷化試劑在藥物合成中的研究與應用 |
| 鄧鋒杰; 陳萍華; 溫遠慶; 蔣華麟(南昌大學(xué)化學(xué)系; 南昌航空工業(yè)學(xué)院環(huán)化系; 江西南昌) |
| 摘 要：綜述了位阻型硅烷化試劑的特點(diǎn)、保護原理和應用。就其在保護含雜原子的有機官能 團方面討論了對羥基、羧基、羰基及胺基等的保護和去保護條件及其在藥物合成中的應用。并對位 阻型硅烷化試劑的發(fā)展趨勢進(jìn)行展望。 |
| 關(guān)鍵詞：位阻型; 氯硅烷; 保護基團; 藥物合成; 選擇性 |
| 中圖分類(lèi)號：O662 TQ46 TQ61 文獻標識碼：A 文章編號：1009-9212(2005)05-0006-04 |
|
| Application of Organosilan as a Protective Reagent in the Synthesis of Pharmaceuticals |
| DENG Feng-jie; CHEN Ping-hua; WEN Yuan-qing; JIANG Hua-lin Department of Chemistry; Nanchang University. Nanchang 330047. China; Department of Enviroment and Chemistry; Nanchang Aviation Industry University; Nanchang 330034; China |
| Abstract：The characteristics, protective principle and application of Sterically hindered silane blocking agents were reviewed. Organochlorosilane is widely used in the protection of organic functional groups involving hetero atoms, such as hydroxyl, carboxyl, carbonyl, amino group and so on .The conditions of protection and deprotection and the application development in the synthesis of pharmaceuticals are given in the article. Its trend of development is viewed in this article. |
| Key words：Sterically hindered; Organochlorosilane; protective group; synthesis of pharmaceuticals; selective |
|
基金項目：江西省自然科學(xué)基金資助項目(No.0520038)
|
收稿日期：2005-08-15
|
| 閱讀全文 |
|