| 第 35 卷第 6 期 |  | Vol. 35 No. 6 | | 2005 年 12 月 | Dec 2005 |
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所屬欄目：有機合成原料
相轉移催化合成2,2-二羥甲基丙酸(DMPA)的研究 |
| 趙進(jìn); 黃祖良; 莫長(cháng)姣; 陳潔(右江民族醫學(xué)院化學(xué)教研室; 廣西百色) |
| 摘 要：以甲醛和丙醛為原料,在相轉移催化作用下經(jīng)羥醛縮合及氧化反應合成了2,2一二羥甲基丙酸(DMBA)�？s合反應在30℃,n(甲醛)/n(丙醛)=2.2,催化劑為十六烷基三甲基溴化銨(HDTMA),用Na2CO3和Na0H的混合堿調pH=9,反應2h。反應后立即加鹽酸中和調pH=5;氧化反應在70℃、反應時(shí)間2.5h。反應產(chǎn)物的結構用紅外光譜(IR)表征。 |
| 關(guān)鍵詞：2; 2一二羥甲基丙醛; 2一二羥甲基丙酸; 相轉移催化反應; 縮合反應; 氧化反應 |
| 中圖分類(lèi)號：TQ225.12+3 文獻標識碼：A 文章編號：1009-9212(2005)06-0044-03 |
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| Synthesis of 2,2-dimethylolbutyric acid |
| ZHAO Jin; HUANG Zu-liang; MO Changjiao; CHEN Jie（Department of Chemistry; You jiang Medical College for Nationlities; Baise 533000; China） |
| Abstract：Using phase transfer catalyst,2,2-dimethylolbutyric acid was prepared by the aldol condensation and oxidation from formaldehyde and propionaldehyde.The most suitable technological conditions for the aldol condensation were as follows: phase transfer catalyst was HDTMAB;molar ratio n(formaldehyde)∶ n(propionaldehyde)=2.2∶1;pH=10;reaction temperature 30℃,and reaction time 2.0 h.The most suitable technological conditions for the oxidation were as follows: pH =4;reaction temperature 70℃,and reaction time 2.5h.T... |
| Key words：2; 2-dimethylolbutyric acid; phase transfer catalytic reaction; aldol condensation |
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收稿日期：2005-09-10
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