| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所屬欄目：醫藥及中間體
5-溴乙�；畻铛０返闹苽� |
| 徐娟娟; 胡艾希; 王宇; 羅成禮(湖南大學(xué)化學(xué)化工學(xué)院; 湖南長(cháng)沙) |
| 摘 要：5-溴乙�；畻铛０肥且环N非常重要的醫藥與農藥中間體。選擇溴在乙酸溶劑中,5-乙�；畻铛０蜂寤�。當反應物n(5-乙�；畻铛０�)∶n(溴)=1∶1.05,5℃反應12h,可高選擇性得到5-溴乙�；畻铛０�,收率93.2%。 |
| 關(guān)鍵詞：α-溴化反應; 5-溴乙�；畻铛０�; 5-乙�；畻铛０� |
| 中圖分類(lèi)號：TQ225.26+1 文獻標識碼：A 文章編號：1009-9212(2006)02-0032-02 |
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| Synthesis of 5-(Bromoacetyl) salicylamide |
| XU Juan-juan; HU Ai-xi*; WANG Yu; LUO Cheng-li（College of Chemistry and Chemical Engineering; Hunan University; Changsha 410082; China） |
| Abstract：5-(Bromoacetyl)salicylamide is an important intermediate of medicine and pesticide. 5-Acetyl salicylamide was brominated by bromine to give 5-(bromoacetyl)-salicylamide in high selectivity. The yield was 93.2% when the molar ratio of 5-acetyl salicylamide to bromine was 1 ∶ 1.05 at 5 ℃ for 12 h. |
| Key words：α-bromination; 5-（bromoacetyl）salicylamide; 5-acetyl salicylamide |
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收稿日期：2005-12-02
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