| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所屬欄目：農藥及中間體
鄰硝基芐基溴的合成研究 |
| 蘭世林; 劉衛東; 蘭支利(湖南師范大學(xué)化學(xué)化工學(xué)院; 湖南化工研究院; 湖南長(cháng)沙) |
| 摘 要：對以鄰硝基甲苯為原料,NaBrO3/NaHSO3為溴化劑,偶氮雙異丁腈(AIBN)為引發(fā)劑,制備鄰硝基芐基溴的工藝路線(xiàn)進(jìn)行了研究,在優(yōu)惠的工藝條件下n(鄰硝基甲苯)∶n(溴酸鈉)∶n(亞硫酸氫鈉)=1∶4∶4,反應溫度70℃,時(shí)間2h,反應收率≥73%。該工藝具有生產(chǎn)成本低、操作簡(jiǎn)便和易于工業(yè)化生產(chǎn)等特點(diǎn)。 |
| 關(guān)鍵詞：鄰硝基芐基溴; 合成; 鄰硝基甲苯 |
| 中圖分類(lèi)號：TQ246.1+2 文獻標識碼：A 文章編號：1009-9212(2006)02-0024-02 |
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| Synthesis of O-Nitrobenzyl Bromide |
| LAN Shi-lin1; LIU Wei-dong*; 2; LAN Zhi-li1（1. College of Chemistry and Chemical Engineering; Hunan Normal University; Changsha 410081; China; 2. Hunan Research Institute of Chemical Industry; Changsha 410007; China） |
| Abstract：A new method of preparation o-nitrobenzyl bromide using o-nitrotoluene as raw material, NaBrO3/NaHSO3 as bromination agent and AIBN as initiator was developed,under the optimum conditions n(o-nitrotoluene) ∶ n(sodium bromate) ∶ n(sodium bisulfite)=1 ∶ 4 ∶ 4,reaction terperature 70 ℃,reaction time 2 h,the yield is up to 73%. This process is easy to scale up with lower material cost,simple and convenient operation. |
| Key words：o-nitrobenzyl bromide; synthesis; o-nitrotoluene |
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基金項目：湖南省杰出青年科學(xué)基金資助項目(No.04JJ1009)
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收稿日期：2006-02-22
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