| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所屬欄目：農藥及中間體
喹啉酸的合成研究 |
| 段湘生; 聶萍(湖南化工研究院; 湖南長(cháng)沙) |
| 摘 要：以喹啉為起始原料,經(jīng)過(guò)氧化、堿解、酸化合成醫藥中間體喹啉酸,詳細考察了氧化反應時(shí)間,加料方式,催化劑用量對反應的影響,獲得了喹啉酸合成優(yōu)惠反應條件:n(喹啉)∶n(氯酸鈉)∶n(五水硫酸銅)∶n(硫酸)∶n(催化劑)=1∶5∶1.3∶4∶0.0005,氯酸鈉滴加溫度97￣103℃,滴加氯酸鈉時(shí)間20h。用此法合成喹啉酸,產(chǎn)品總收率74.5%,產(chǎn)品純度98.2%。 |
| 關(guān)鍵詞：喹啉酸; 中間體; 喹啉 |
| 中圖分類(lèi)號：O626.32+3 文獻標識碼：A 文章編號：1009-9212(2006)02-0018-03 |
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| Synthesis of Quinolinic Acid |
| DUAN Xiang-sheng; NIE Ping（Hunan Research Institute of Chemical Industry; Changsha 410007; China） |
| Abstract：Quinolinic acid was synthesized from cheap materials quinoline via oxidation,alkalization,and acidification. Effect of oxidation time,material addition pattern and catalyst amount on synthesis of quinolinic acid was investigated. The optimal conditions were as follow:molar ratio of quinolinic,sodium chlorate,copper sulphate,sulfuric acid and catalyst was 1 ∶ 5 ∶ 1.3 ∶ 4 ∶ 0.000 5. Sodium chlorate at dropped in the sotution at 97~103 ℃,within 20 h. The total yield and purity of quinolinic acid was 74.5% and ... |
| Key words：quinolinic acid; intermediate; quinoline |
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收稿日期：2006-02-10
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