| 第 36 卷第 3 期 |  | Vol. 36 No. 3 | | 2006 年 6 月 | Jun 2006 |
|
所屬欄目：農藥及中間體
利用Mitsunobu反應合成芳基吡啶烷基醚 |
| 唐子龍(湖南科技大學(xué)化學(xué)化工學(xué)院; 湖南湘潭) |
| 摘 要：在室溫下,以取代苯酚1a-b和吡啶烷基醇2a-d為原料通過(guò)Mitsunobu反應合成了相應的芳基吡啶烷基醚,反應收率為45%￣70%,反應物2和1之比為1.11∶(摩爾比)。結果表明當酚的6-位取代基為甲氧基時(shí),產(chǎn)物的收率比6-位上沒(méi)有取代基時(shí)的收率高;溶劑對反應收率的影響不大。并用1H NMR、13C NMR和MS等對產(chǎn)物的結構進(jìn)行了測定。 |
| 關(guān)鍵詞：醚; Mitsunobu反應; 合成 |
| 中圖分類(lèi)號：TQ223.2+4 文獻標識碼：A 文章編號：1009-9212(2006)03-0023-05 |
|
| Synthesis of Aryl Pyridylalkyl Ethers by Mitsunobu Reaction |
| TANG Zi-long1; 2（1.School of Chemistry and Chemical Engineering; Hunan University of Science and Technology; Xiangtan 411201; China; 2.Faculty of Pharmacy; University of Paris-sud; 5; rue Jean-Baptiste Clement 92296 Chatenay-Malabry Cedex; France） |
| Abstract：A few of aryl pyridylalkyl ethers were synthesized by Mitsunobu reaction from substituted phenols 1a-b and pyridyl alcohols 2a-e at room temperature in 45%~70% yields.The ratio of 2 to 1 is 1.1 ∶ 1(mol/mol).The yield of the reaction of 2-iodo-6-phenol was higher than those obtained with 2-iodo-phenol,and the solvent has little effect on the yield of the reaction.The structure of the products were assigned with 1H NMR?13C NMR and MS. |
| Key words：ether; Mitsunobu reaction; synthesis |
|
收稿日期：2006-03-23
|
| 閱讀全文 |
|