| 第 36 卷第 3 期 |  | Vol. 36 No. 3 | | 2006 年 6 月 | Jun 2006 |
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所屬欄目：醫藥及中間體
4-氯丁酰氯的合成研究 |
| 牛宇嵐; 李敏; 段海龍(中北大學(xué)分�；瘜W(xué)工程系; 山西太原) |
| 摘 要：以-γ丁內酯為原料、無(wú)水氯化鋅作催化劑、氯化亞砜做氯化劑進(jìn)行開(kāi)環(huán)氯化合成4-氯丁酰氯。對該氯化反應原理進(jìn)行了闡述,考察了影響反應的主要因素。優(yōu)化工藝條件為:在55℃加熱攪拌反應22h,催化劑用量3%～5%,收率82.7%。 |
| 關(guān)鍵詞：-γ丁內酯; 4-氯丁酰氯; 氯化 |
| 中圖分類(lèi)號：TQ225.22 文獻標識碼：A 文章編號：1009-9212(2006)03-0021-02 |
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| Synthesis of 4-Chlorobutyryl Chloride |
| NIU Yu-lan; LI Ming; DUAN Hai-long（Department of Chemical Engineering; College of NorthChina Institute of Technology; Taiyuan 030008; China） |
| Abstract：The synthesis of 4-chlorobutyryl chloride was described using γ-butyroctone as material,anhydrous zinc chloride as the catalyst and thionyl chloride as chloridum.The reaction principle is expounded,and the main factors affecting the reaction are investigated.Optimal conditions were obtained as follow:reaction temperature is 55℃,reaction time 22 h and percent amount of catalyst 3%~5%.The yield of the product is 82.7% under the optimal conditions. |
| Key words：γ-Butyroctone; 4-Chlorobutyryl chloride; Chlorination |
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收稿日期：2006-01-13
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