| 第 36 卷第 3 期 |  | Vol. 36 No. 3 | | 2006 年 6 月 | Jun 2006 |
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所屬欄目：醫藥及中間體
那格列奈的合成工藝研究 |
| 鄧燕; 蔣歡妹; 謝維躍; 陶德良(湖南工業(yè)大學(xué)綠色包裝與生物納米技術(shù)應用重點(diǎn)實(shí)驗室; 湖南輕工研究院; 湖南株洲; 湖南長(cháng)沙) |
| 摘 要：對那格列奈的生產(chǎn)工藝中的反應時(shí)間、溫度、試劑的選擇等進(jìn)行探索、改進(jìn),選用對異丙基苯甲酸為起始原料,采用低壓氫化,直接堿性轉位得對異丙基環(huán)己酸,并用三氯化磷酰氯化后與苯丙氨酸甲酯縮合制得那格列奈,總收率50.76%。 |
| 關(guān)鍵詞：那格列奈; 藥物; 合成 |
| 中圖分類(lèi)號：R977.1+5 文獻標識碼：A 文章編號：1009-9212(2006)03-0019-02 |
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| Synthesis of Antidiabetic Drug Nateglinide |
| DENG Yan;JIANG Huan-mei;XIE Wei-yue;TAO De-liang(Key Laboratory of Green Packaging and Biological Nanotechnology of Hunan Province;Hunan University of Technology;Zhuzhou 412008;China;Hunan Light Industry Research Institute;Changsha 410015; China) |
| Abstract：Nateglinide is a kind of new antidiabetic drug,which has a wide market prospect.In view of the present problems in the synthesis of nateglinide,the optimum synthesis conditions such as reaction time,temperature and reagent,etc were investigated and improved.Nateglinide was synthesized from 4-isopropylbenzonic acid as starting material through low-pressure catalytic hydrogenation,alkalescence displacement and condensation and the total yield was 50.76%. |
| Key words：nateglinide; drug; synthesis |
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收稿日期：2006-02-17
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