| 第 36 卷第 4 期 |  | Vol. 36 No. 4 | | 2006 年 8 月 | Aug 2006 |
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所屬欄目：農藥及中間體
粉唑醇的合成 |
| 曹偉鋒; 廖道華; 雷子蕙(華東理工大學(xué)制藥工程系) |
| 摘 要：粉唑醇是用于植物葉片和穗的廣譜殺菌劑,對谷物白粉病、云形病、葉斑病和銹病都有效。本文以鄰氟溴苯為原料經(jīng)格氏反應合成1-(2-氟苯基)-1-(4-氟苯基)-2-氯乙醇,然后與1,2,4-三唑鈉鹽反應得到標題化合物�？偸章蔬_59%,含量94.5%。 |
| 關(guān)鍵詞：殺菌劑; 粉唑醇; 氯乙醇; 格氏反應; 鄰氟溴苯; 合成 |
| 中圖分類(lèi)號：TQ455.4+7 文獻標識碼：A 文章編號：1009-9212(2006)04-0033-02 |
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| Synthesis of Fungicide Flutriafol |
| CAO Wei-feng. LIAO Dao-hua; LEI Zi-hui （Pharmaceutical Department of East China University of Science and Technology; Shanghai 200237; China） |
| Abstract：Flutriafol was a kind of broad-spectrum fungicide that could be used to control effectively cereal powdery mildew,cloud disease,leaf spot disease and rust disease. 1-o-fluorophenyl-1-p-fluorophenyl-2-chloroethanol was prepared through Grignard reaction starting with 2-fluorobenzyl bromide,and then reacted with sodium triazol to give the title product flutriafol. The total yield and purity were 59% and 94.5%,respectively. |
| Key words：fungicide; flutriafol; ethanolyl chloride; Grignard reaction; o-fluorobenzyl bromide; synthesis |
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收稿日期：2006-03-16
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