| 第 36 卷第 4 期 |  | Vol. 36 No. 4 | | 2006 年 8 月 | Aug 2006 |
|
所屬欄目：醫藥及中間體
齊多夫定脫保護副產(chǎn)物的結構鑒定及其應用研究 |
| 朱建明(廈門(mén)邁克制藥有限公司; 福建廈門(mén)) |
| 摘 要：采用FT-IR、MS、NMR等波譜技術(shù)對齊多夫定(AZT)脫保護副產(chǎn)物進(jìn)行結構鑒定,確定了其結構為三苯甲基甲醚,并開(kāi)發(fā)了其商業(yè)應用技術(shù)。在HCl作用下完成醚鍵斷裂,把三苯甲基甲醚轉化為三苯基氯甲烷,收率95.8%,該產(chǎn)物可再次應用到合成AZT的合成過(guò)程中,降低其生產(chǎn)成本。 |
| 關(guān)鍵詞：三苯基氯甲烷; 三苯甲基甲醚; 副產(chǎn)物; 結構 |
| 中圖分類(lèi)號：R914.5 文獻標識碼：A 文章編號：1009-9212(2006)04-0026-02 |
|
| The Structural Identification of the Byproduct from Zidovudine and it's Application |
| ZHU Jian-ming （Xiamen Mchem Laboratories LTD.; Xiamen 361022; China） |
| Abstract：A large number of byproduct was received in deprotection step of synthesis Zidovudine,the work for it's structural identification had been completed. The trityl methyl ether can react with hydrogen chloride and get the commercial chemical material trityl chloride with high yield. |
| Key words：trityl chloride; trityl methyl ether; outgrowth; structural identification |
|
收稿日期：2006-03-20
|
| 閱讀全文 |
|