| 第 36 卷第 4 期 |  | Vol. 36 No. 4 | | 2006 年 8 月 | Aug 2006 |
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所屬欄目：醫藥及中間體
2,3-二氯苯甲酸的合成研究 |
| 廖齊; 鄧洪(中南林業(yè)科技大學(xué)理學(xué)院; 湖南株洲) |
| 摘 要：2,3-二氯苯甲酸是合成特效抗癲癇藥拉莫三嗪及其它治療中樞神經(jīng)紊亂藥物的重要中間體。筆者用2,3-二氯苯胺經(jīng)重氮化、邁爾瓦音反應制得2,3-二氯苯甲醛,再經(jīng)高錳酸鉀氧化制得2,3-二氯苯甲酸,總收率45%。對各步反應的操作及產(chǎn)品的純化方法進(jìn)行了研究。 |
| 關(guān)鍵詞：2; 3-二氯苯甲酸; 3-二氯苯甲醛; 抗癲癇; 拉莫三嗪; 中間體; 合成 |
| 中圖分類(lèi)號：TQ245.3 文獻標識碼：A 文章編號：1009-9212(2006)04-0018-03 |
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| Synthesis of 2,3-Dichlorobenzoic Acid |
| LIAO Qi; DENG Hong （Department of Chemistry; Central South University of Forestry and Technology; Zhuzhou 412006; China） |
| Abstract：2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug lamotrigine and the other medicine for the treatment of central nervous system (CNS)disorders and disease. 2,3-Dichlorobenzoic acid was prepared through diazotization and Meerwein reaction to give 2,3-dichlorobenzaldehyde from 2,3-dichloroaniline and followed by oxidation with potassium permanganate,and the overall yield was 45%. In addition,each operation of the reactions and purification was also studied . |
| Key words：2; 3-dichlorobenzoic acid; 3-dichlorobenzaldehyde; antiepileptic; lamotigine; intermediate; synthesis |
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基金項目：中南林學(xué)院引進(jìn)高層次人才科研基金項目(0113)
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收稿日期：2006-06-05
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