| 第 36 卷第 5 期 |  | Vol. 36 No. 5 | | 2006 年 10 月 | Oct 2006 |
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所屬欄目：農藥及中間體
2-巰基-3-芐氧基吡啶的合成 |
| 皮紅軍; 廖道華; 董捷; 王宏健; 樓江松(華東理工大學(xué)制藥工程系) |
| 摘 要：報道了超高效除草劑三氟啶磺隆的中間體2-巰基-3-芐氧基吡啶的合成方法。首先以2-氯-3-羥基吡啶(2)為原料,與溴化芐(3)在丙酮中反應制備2-氯-3-芐氧基吡啶(4);化合物4再與硫脲在無(wú)水乙醇反應得到2-巰基-3-芐氧基吡啶�？偸章�75.61%。 |
| 關(guān)鍵詞：除草劑; 三氟啶磺隆; 2-巰基-3-芐氧基吡啶; 2-氯-3-羥基吡啶 |
| 中圖分類(lèi)號：TQ457.2 文獻標識碼：A 文章編號：1009-9212(2006)05-0047-03 |
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| Synthesis of 2-Mercapto-3-benzyloxypyridine |
| PI Hong-jun; LIAO Dao-hua; DONG Jie; WANG Hong-jian; LOU Jiang-song（College of Chemistry and Pharmaceutical Engineering; East China University of Science and Technology; Shanghai 200237; China） |
| Abstract：2-Mercapto-3-benzyloxypyridine(1)was an important intermediate of herbicide trifloxysulfuron.A new practical synthesis method of 2-mercapto-3-benzyloxypyridine(1)was described in the paper.2-Chloro-3-hydroxylpyridine was treated with 1.0 equiv.of benzyl bromide in acetone to form 2-chloro-3-benzyloxypyridine(4)in 97% yield.The compound 4 then reacted with 1.2 equiv.of thiourea in anhydrous ethanol to produce 2-mercapto-3-benzyloxypyridine(1)in 77.95% yield.The total yield of the product was 75.61%. |
| Key words：herbicide; trifloxysulfuron; 2-mercapto-3-benzyloxypyridine; 2-chloro-3-hydroxylpyridine; synthesis |
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收稿日期：2006-06-28
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