| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所屬欄目：分析與測試
雷洛昔芬中間體4-甲氧基-α-[(3-甲氧基苯基)硫代]苯乙酮含量的反相高效液相色譜測定 |
| 張艷林; 胡德禹; 宋寶安; 盧平; 楊松; 樊玲娥; 劉平生; 薛偉(貴州大學(xué)精細化工研究開(kāi)發(fā)中心; 貴州貴陽(yáng); 綠色農藥與生物工程教育部重點(diǎn)實(shí)驗室) |
| 摘 要：采用反相高效液相色譜法,以v(甲醇)v∶(水)=802∶0作為流動(dòng)相,用C18柱和二極管陣列檢測器(DAD,282nm),測定4-甲氧基--α[(3-甲氧基苯基)硫代]苯乙酮的含量。結果表明,4-甲氧基--α[(3-甲氧基苯基)硫代]苯乙酮在0.02～0.90μg內呈良好的線(xiàn)性關(guān)系,r=0.99999。該方法靈敏、快速、準確,可用于4-甲氧基--α[(3-甲氧基苯基)硫代]苯乙酮含量的測定。 |
| 關(guān)鍵詞：4-甲氧基-α-[（3-甲氧基苯基）硫代]苯乙酮; 檢測; 高效液相色譜 |
| 中圖分類(lèi)號：O657.7+2 文獻標識碼：A 文章編號：1009-9212(2006)06-0065-03 |
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| Determination of Content of Raloxifen Intermediate 4-Methoxy-α-[(3-methoxyphenyl)thio]Acetophenone by R-HPLC |
| ZHANG Yan-lin;HU De-yu;SONG Bao-an;LU ping;YANG Song;FAN Ling-e;LIU Ping-sheng;XUE Wei(Center for Research and Development of Fine Chemicals;China;Key Laboratory of Green Pesticide and Bioengineering;Ministry of Education;GuiZhou University) |
| Abstract：A quantitative analytical method of 4-Methoxy-α-[(3-Methoxyphenyl)thio] acetophenone by R-HPLC was described,using v(methanol) ∶ v(water) = 80 ∶ 20 as mobile phase,using Kromasil C18 column at DAD detector(282 nm).Result showed that 4-methoxy-α-[(3-methoxyphenyl)thio] acetophenone was linear(r = 0.999 99)and had a good linear correlation in the range of 0.02~0.90 μg,This suggested that the method was proved to be sensitive,fast and accurate,and could be used for determining the content of 4-methoxy-α-[(3-me... |
| Key words：4-methoxy-α-[（3-methoxyphenyl）thio]acetophenone; determination; HPLC |
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基金項目：貴州省省長(cháng)基金項目(2005374)
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收稿日期：2006-10-23
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