| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所屬欄目：農藥及中間體
2,4-二氯苯并噻唑的合成研究 |
| 許標; 蘭支利(湖南師范大學(xué); 湖南長(cháng)沙; 長(cháng)沙醫學(xué)院; 410219) |
| 摘 要：以2-氨基-4-氯苯并噻唑為原料,在酸性條件下與亞硝酸鈉反應,再水解生成2,4-二氯苯并噻唑。探討了亞硝酸鈉的用量、反應溫度和反應時(shí)間3個(gè)因素對產(chǎn)物收率的影響,優(yōu)化了合成工藝。在優(yōu)化條件下,產(chǎn)品收率為91.9%,純度達98.6%。 |
| 關(guān)鍵詞：2-氨基-4-氯苯并噻唑; 亞硝酸鈉; 重氮化 |
| 中圖分類(lèi)號：O626.25 文獻標識碼：A 文章編號：1009-9212(2006)06-0035-02 |
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| Synthesis of 2,4-Dichlorbenzothiazole |
| XU Biao1; 2; LAN Zhi-li1（1.Hunan Normal Univesity; Changsha 410001; China; 2.Changsha Medical College; Changsha 410229; China） |
| Abstract：2,4-Dichlorbenzothiazole was prepared from 2-amino-4-chlorbenzothiazole through diazotization and hydrolysis.The amount of sodium nitrite,reaction temperature and time were the main effective factors,and the optimum synthesis conditions were obtained.The yield and purity of the product reached 91.9% and 98.6%,respectively,under the optimal conditions. |
| Key words：2-amino-4-chlorbenzothiazole; sodium nitrite; diazotization reaction |
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收稿日期：2006-08-26
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