| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所屬欄目：農藥及中間體
對乙氧基苯乙酸的合成研究 |
| 叢杉; 王濤; 沈德隆; 孫娜波(浙江工業(yè)大學(xué)化學(xué)工程與材料學(xué)院; 浙江新迪國際食品有限公司; 浙江杭州) |
| 摘 要：以對羥基苯乙酸為原料,分別采用溴乙烷和硫酸二乙酯為醚化試劑,經(jīng)Williamson醚化合成了對乙氧基苯乙酸。通過(guò)正交實(shí)驗得出兩條路線(xiàn)的較優(yōu)合成條件:溴乙烷法中,n(對羥基苯乙酸)n∶(溴乙烷)=11∶.6,反應溫度68℃,反應時(shí)間5h,收率85%左右;硫酸二乙酯法中,n(對羥基苯乙酸)n∶(硫酸二乙酯)n∶(氫氧化鈉)=1∶2.5∶2.4,反應溫度80℃,收率在90%以上。 |
| 關(guān)鍵詞：對乙氧基苯乙酸; 溴乙烷; 硫酸二乙酯; 合成 |
| 中圖分類(lèi)號：TQ245.1+3 文獻標識碼：A 文章編號：1009-9212(2006)06-0032-03 |
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| Synthesis of 4-Ethoxyphenylacetic Acid |
| CONG Shan1; WANG Tao2; SHEN De-long1; SUN Na-bo1（1.Institute of Pesticide; Zhejiang University of Technology; Hangzhou 310032; China; 2.Zhejiang Xindi International Food Co.Ltd; Hangzhou 310006; China） |
| Abstract：4-Ethoxyphenylacetic acid was synthesized from 4-hydroxyphenylacetic acid by the Williamson etherization reaction.Ethyl bromide and diethyl sulfate were used as etherization reagents,respectively.By experiments utilizing an orthogonal design,optimum synthesis conditions were obtained as follows: in the ethyl bromide route,the molar ratio of 4-hydroxyphenylacetic acid to ethyl bromide was 1 ∶ 1.6,the reaction temperature was 68℃,the reaction time was 5 h and the yield was about 85%.In the diethyl sulfate rou... |
| Key words：4-ethoxyphenylacetic acid; ethyl bromide; diethyl sulfate; synthesis |
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收稿日期：2006-10-18
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