| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所屬欄目：醫藥及中間體
微波輻射法合成5-取代四氮唑衍生物 |
| 姜鳳超; 王靜(華中科技大學(xué)同濟醫學(xué)院藥學(xué)院; 湖北武漢) |
| 摘 要：研究了將氰化物與疊氮化合物在微波輻射條件下反應,得到5-取代四氮唑合成了4個(gè)5-芳香取代的四氮唑衍生物,所得產(chǎn)物經(jīng)IR,NMR鑒定。與原有方法相比,微波輻射法反應時(shí)間大大縮短(由幾十小時(shí)縮短為幾十分鐘),還具有收率較高、后處理簡(jiǎn)單等優(yōu)點(diǎn)。 |
| 關(guān)鍵詞：微波輻射; 四氮唑衍生物; 合成 |
| 中圖分類(lèi)號：O623.626 文獻標識碼：A 文章編號：1009-9212(2006)06-0022-04 |
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| Synthesis of 5-Substituted Tetrazole Derivatives by Microwave Radiation Method |
| JIANG Feng-chao; WANG Jing（School of Pharmacy; Tongji Medical College of HUST; Wuhan 430030; China） |
| Abstract：Tetrazole derivatives have been extensively used in medicine,but there were some disadvantages in its classic synthetic method such as long reaction time(tens hours,even several days),low yield and the troublesome after-treatment.Using microwave irradiation method four 5-substitued tetrazole derivatives were prepared in 30 minutes,and the optimum reaction condition was obtained.The target compounds were identical with the document. |
| Key words：microwave radiation; tetrazole derivatives; synthesis |
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收稿日期：2006-09-28
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