| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所屬欄目：醫藥及中間體
5-羥基色滿(mǎn)的合成 |
| 黃二芳; 朱麗丹; 孫蕊; 金麗萍; 胡春(沈陽(yáng)藥科大學(xué)制藥工程學(xué)院; 遼寧沈陽(yáng)) |
| 摘 要：以2',6'-二羥基苯乙酮為起始原料,在鈉催化下和甲酸乙酯縮合制得5-羥基-4-色酮,然后催化氫化還原得到5-羥基-4-色滿(mǎn)酮,最后用鋅汞齊還原制得5-羥基色滿(mǎn)。所設計的5-羥基色滿(mǎn)合成路線(xiàn)總收率能達到37%,是合成5-羥基色滿(mǎn)的新路線(xiàn)。 |
| 關(guān)鍵詞：藥物化學(xué); 5-羥基色滿(mǎn); 5-羥基-4-色酮; 5-羥基-4-色滿(mǎn)酮; 合成; Clemmensen還原; 催化氫化 |
| 中圖分類(lèi)號：TQ225.2 文獻標識碼：A 文章編號：1009-9212(2006)06-0020-02 |
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| Study on Synthesis of 5-Hydroxychroman |
| HUANG Er-fang; ZHU Li-dan; SUN Rui; JIN Li-ping; HU Chun; （School of Pharmaceutical Engineering; Shenyang Pharmaceutical University; Shenyang 110016; China） |
| Abstract：5-Hydroxychroman was prepared by Clemmensen reduction from 5-hydroxy-4-chromanone,whereas 5-hydroxy-4-chromanone was prepared by catalytic hydrogenation from 5-hydroxy-4-chromone which was prepared from2',6'-dihydroxyacetophenone.5-Hydroxychroman can be synthesized with total yield of 37% according to the novel procedure reported in this paper. |
| Key words：medicinal chemistry; 5-hydroxychroman; 5-hydroxy-4-chromone; 5-hydroxy-4-chromanone; synthesis; clemmensen reduction; catalytic hydrogenation |
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基金項目：國家自然科學(xué)基金資助項目(20472053)
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收稿日期：2006-10-29
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