| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所屬欄目：醫藥及中間體
新型喹唑啉化合物的合成與生物活性 |
| 薛偉; 宋寶安; 楊松; 胡德禹; 劉剛; 劉平生; 張培權; 金林紅; 張素梅(貴州大學(xué)精細化工研究開(kāi)發(fā)中心; 貴州貴陽(yáng); 教育部綠色農藥與農業(yè)生物工程重點(diǎn)實(shí)驗室) |
| 摘 要：設計并合成4類(lèi)新型喹唑啉化合物,進(jìn)行醫藥和農藥的聯(lián)合篩選,生物活性測試表明部分新化合物具有較好的生物活性。 |
| 關(guān)鍵詞：喹唑啉; 中間體; 生物活性 |
| 中圖分類(lèi)號：O626 文獻標識碼：A 文章編號：1009-9212(2006)06-0016-04 |
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| Synthesis and Application of Novel Intermediate of Quinazoline Compounds |
| XUE Wei;SONG Bao-an;YANG Song;HU De-yu;LIU Gang;LIU Ping-sheng;ZHANG Pei-quan;JIN Lin-hong;ZHANG Su-mei(Research and Development Center for Fine Chemicals of Guizhou University;Key Laboratory of Green Pesticide and Agriculture Bioengineering... |
| Abstract：Four kinds of novel quinazoline compounds were designed and synthesized for the joint development of medicine and pesticides in this paper.The bioassay results showed that some new compounds had good inhibitory activity against growth of crop pathogenic fungi and ERK 1/2 phosphorylation of PC3 cells. |
| Key words：quinazoline; intermediate; bioactivity |
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基金項目：國家重點(diǎn)基礎研究發(fā)展計劃“973”計劃(2003CB114404);國家自然科學(xué)基金(20442003,20562003);貴州省省長(cháng)資金項目資助
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收稿日期：2006-08-31
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