| 第 37 卷第 6 期 |  | Vol. 37 No. 6 | | 2007 年 12 月 | Dec 2007 |
|
所屬欄目：農藥及中間體
丙酮肟法合成乙氧基胺鹽酸鹽 |
| 潘忠穩，李玉喜，夏 嵐
（安徽大學(xué) 化學(xué)化工學(xué)院，安徽 合肥 230039） |
| 摘 要：通過(guò)三步反應合成乙氧基胺鹽酸鹽，采用鹽酸羥胺和丙酮反應制備丙酮肟，經(jīng)硫酸二乙酯乙基化、鹽酸水解合成乙氧基胺鹽酸鹽。實(shí)驗考察了反應溫度、催化劑量、反應時(shí)間對乙基化反應的影響。結果表明：在無(wú)催化劑條件下，25℃下反應6 h，O-乙基丙酮肟收率87.6%（以丙酮肟計），產(chǎn)品總收率為66.7%（以鹽酸羥胺計）。 |
| 關(guān)鍵詞：丙酮肟；O-乙基丙酮肟；乙氧基胺鹽酸鹽；合成 |
| 中圖分類(lèi)號：O625.6 文獻標識碼：A 文章編號：1009-9212（2007）06- 0017-02 |
|
| Synthesis of Ethoxyamine Hydrochloride via Acetoxime |
| PAN Zhong-wen，LI Yu-xi，XIA Lan
（School of Chemistry & Chemical Engineering，Anhui University，Hefei 230039，China） |
| Abstract：Ethylamine hydrochloride as pesticide and pharmaceutical intermediates was synthesized through three step reactions. Hydroxylamine hydrochloride was contacted with acetone to give acetoxime then acetoxime was alkylated by diethyl sulfate to form O-ethylacetoxime，and finally，O-ethylacetoxime was hydrolyzed by hydrochloric acid to obtain ethylamine hydrochloride . The process of the reaction was optimized as follow：acetoxime reacted with diethyl sulfate for 6 h at 25℃ without catalyst to give O-ethylacetoxime with 87.6% of yield baseed on acetoxime. The total yield of product was 66.7% based on hydroxylamine hydrochloride. |
| Key words：alkylamine hydrochloride；acetoxime；O-ethylacetoxime；synthesis |
|
作者簡(jiǎn)介：潘忠穩（1963-），男，安徽合肥人，高級工程師，碩士，從事農藥及精細化學(xué)品的合成、分析研究。（E-mail：ahpzw@163.com）
|
收稿日期：2007-09-13
|
|